参考文献
Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms
Carcinogenesis (1999) 20 (11): 2095-2100
Effects of orally administered glycine on myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle in chicks.
Amino Acids. 2008 Aug;35(2):451-6. Epub 2007 Jul 12
Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine.
Neuroscience. 2008 Apr 22;153(1):154-61. doi: 10.1016/j.neuroscience.2008.02.009. Epub 2008 Feb 19
Pharmacokinetics and cerebral distribution of glycine administered to rats.
Amino Acids. 2012 Jun;42(6):2129-37. doi: 10.1007/s00726-011-0950-y. Epub 2011 Jun 7
Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia.
Arch Gen Psychiatry. 1999 Jan;56(1):29-36
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects
Scientific Reports 5, Article number: 10434 (2015)
Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes
J Endocrinol Invest. 2008 Aug;31(8):694-9
Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells
Am J Surg. 2008 Jul;196(1):139-48. doi: 10.1016/j.amjsurg.2007.09.045
Glycine modulates cytokine secretion, inhibits hepatic damage and improves survival in a model of endotoxemia in mice
Liver Int. 2003 Aug;23(4):276-82
Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: beneficial role of glycine
Free Radic Res. 2012 Oct;46(10):1296-307. doi: 10.3109/10715762.2012.712690. Epub 2012 Aug 8
Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. April 2007. Vol 5;2. P 126–131.
Shanahan MD, Catherine (2011-04-22). Deep Nutrition: Why Your Genes Need Traditional Food. Big Box Books. Kindle Edition.
L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot study.
BMC Med. 2011 Apr 18;9:40
L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, placebo-controlled, randomized trial.
J Psychiatr Res. 2014 Dec;59:125-31
Inotropic effects of L-lysine in the mammalian heart
Naunyn Schmiedebergs Arch Pharmacol. 2009 Oct;380(4):293-301
Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria.
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8285-8. Epub 2004 May 24.
Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana.
Am J Clin Nutr. 2010 Oct;92(4):928-39. doi: 10.3945/ajcn.2009.28834. Epub 2010 Aug 18.
Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol Rep. 2005 Oct;14(4):807-15.
Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ. Cancer Res. 2011 May 1;71(9):3306-16
Ottenberg, R, Painless jaundice, Journal of the American Medical Association, 1935, 104, 9, 1681-1687
Stimulation of gastric acid secretion by glycine and related oligopeptides in humans, American Journal of Physiology, 1982, 5, 242, G86-G88.
Minuskin,M et al. 1981, Nitrogen retention, muscle creatine and orotic acid excretion in traumatized rats fed arginine and glycine enriched diets, Journal of Nutrition, 1981, III, 7, 1265-1274.
Carcinogenesis, Vol. 20, No. 5, 793-798, May 1999. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Rose M.L.,Madren J, Bunzendahl H., and Thurman R.G.
Free Radic Biol Med. 2001 Nov 15;31(10):1236-44. Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat. Mauriz JL, Matilla B, Culebras JM, Gonzalez P, Gonzalez-Gallego J.
Arch Gen Psychiatry. 1999; 56:29-36. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Heresco-Levy U, Javitt DC, Ermilov M, et al.
Neurochem Res. 1995 Oct;20(10):1203-10. The influence of glycine and related compounds on spinal cord injury-induced spasticity. Simpson RK Jr, Gondo M, Robertson CS, Goodman JC.
Cell Mol Life Sci.1999; 56:843-856. Glycine: a new anti-inflammatory immunonutrient. Wheeler MD, Ikejema K, Mol Life Sci. Enomoto N, et al.
Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ., “L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent.” Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):229-40.
The main green tea polyphenolepigallocatechin-3-gallate counteractssemen-mediated enhancement of HIV infection I
Ilona Hauber, Heinrich Hohenberg, Barbara Holstermann, Werner Hunstein, and Joachim Hauber PNAS Early Edition、2009
Patterns of MMP-2 and MMP-9 expression in human cancer cell lines
Roomi MW, Monterrey JC, Kalinovsky T, Rath M, Niedzwiecki A
Oncology Reports, 2009, 21, 1323-1333
Suppression of Human Rheumatoid Synovial Fibroblast MMP-2 Expression and Marix Invasion by Nutrient Synergy
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Matthias Rath Research, Cancer Research Division, Santa Clara, CA 95050
Presented at: 9th World Congress of the Osteoarthritis Research Society International, Chicago, Illinois, December 2-5, 2004.
Published in: Osteoarthritis and Cartilage
Nutrient Mixture Prevents Hyper-Reactive Response Of Bronchial Muscle To Inflammatory And Allergic Stimuli.
Ivanov V, Roomi MW, Niedzwiecki A, Rath M
Matthias Rath Research Institute BV, Santa Clara, CA.
Presented at: 46th Annual Meeting of the American College of Nutrition, Charleston, South Carolina, Sept 22-25, 2005.
Published in: Journal of the American College of Nutrition, vol 24(5), Oct 2005
Effects of a nutrient mixture on infectious properties of the highly pathogenic strain of avian influenza virus A/H5N1
Deryabin PG, Lvov DK, Botikov AG, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M
Biofactors, 2008, 33, 85-97
Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids.
Jariwalla R, Roomi MW, Gangapurkar B, Kalinovsky T, Niedzwiecki A, Rath M
Biofactors, 2007, 31 (1),1-15.
Modulation of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in Sprague-Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract
M.W. Roomi, V. Ivanov ,T. Kalinovsky, A. Niedzwiecki, M. Rath
Breast Cancer Research, 2005, 7:R291-R295.
Inhibition of Matrix Metalloprotenase-2 Secretion and Invasion by Human Ovarian Cancer Line SK-OV-3 with Lysine,Proline, Arginine, Ascorbic Acid and Green Tea Extract
Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A,
Rath M
Journal of Obstetrics and Gynecology, 2006, 32 (2), 148-154.
A natural Anti-Cancer formula-A specific formulation of nutrients containing lysine, praline, ascorbic acid, and epigallocatechin gallate inhibits matrix metalloproteinases activity and invasion potential of human cancer cell lines.
Roomi MW , Netke SP, Ivanov V, , Rath M. Niedzwiecki A
European Cancer Journal, 38, Suppl.7/Abs.280,2002
“Botanical Medicine in Clinical Practice”
Chapter 23, “Micronutrients and Nutrient Synergy in Immunodeficiency and Infectious Disease”
Jariwalla R, Niedzwiecki A, Rath M
Watson, R. R. and Preedy, V. R. (eds) (2008), CABI, Wallingford, UK
Inhibitory Effects of Ascorbic Acid, Proline, and Lysine Supplementation on Matrigel Invasion by Human Breast Cancer Cells MDA-MB-231 (2002)
Netke SP, Ivanov V, Roomi MW, Niedzwiecki A, Rath M.
Nutrient Synergy – A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid, and Epigallocatechin Gallate Inhibits Matrix Metalloproteinases Activity and Invasion Potential of Human Cancer Cell Lines (2002)
Room MW, Netke SP, Ivanov V, Niedzwiecki A, Rath M.
Anticancer Effect of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract on Human Renal Adenocarcinoma Line 786-0 (2004)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
The Third International Kidney Cancer Symposium proceedings, Abstract #39, pg 39.
In vitro Expression of MMP-2 and MMP-9 by Human Renal Cell Carcinoma with Modulation by Phorbol Ester, TNF-alpha, Il-1 beta and Lipopolysaccharides (2004)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Third International Kidney Cancer Symposium proceedings, Abstract #40, pg 40.
A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Cancer Cell Lines (2003)
Netke SP, Roomi MW, Roomi NW, Ivanov V, Niedzwiecki A, Rath M.
Research Communications in Pharmacology and Toxicology: Emerging Drugs, 2:37-5, 2003.
Nutrient Synergy – an Important Inhibitor of MMP-2 Expression and Invasion by Human Ovarian Cancer Cell Line SK-OV-3 (2004)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Matthias Rath Research., Cancer Research Division, Santa Clara, CA 95050
Journal of Immunotherapy (Official journal of International Society for Biological Therapy of Cancer) volume 27, number 6, page S8, November/December 2004
.A Novel Approach to Inhibition of Cancer Development by Nutrient Supplement
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Book of Abstracts, 229th ACS National Meeting, Abstract #86
Nutrition Synergy Inhibits MMP Expression and Invasion Potential of Human Lung Carcinoma Cell Line A-549 (2004)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Matthias Rath Research, Cancer Division, Santa Clara, CA 95050
ACN Symposium on Advances in Clinical Nutrition Program, Abstract #50, pg 465
.A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Cancer Cell Lines (2003)
Netke SP, Roomi MW, Roomi NW, Ivanov V, Niedzwiecki A, Rath M.
Research Communications in Pharmacology and Toxicology: Emerging Drugs, 2:37-5, 2003.
Anti-Tumorigenic Activity of Nutrient Synergy in Human Breast Cancer Lines MDA-MB-231 and MCF-7 (2003)
Roomi MW, Ivanov V, Niedzwiecki A, Rath M.
Inhibition of Tumor Growth of Human Breast, Prostate, Colon, and Melanoma Cancer Xenografts by Nutrient Synergy in Nude Mice (2003)
Roomi MW, Roomi NW, Ivanov V, Netke SP, Niedzwiecki A, Rath M.
Conference proceedings
A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Cancer Cell Lines (2003)
Netke SP, Roomi MW, Roomi NW, Ivanov V, Niedzwiecki A, Rath M.
Research Communications in Pharmacology and Toxicology: Emerging Drugs, 2:37-5, 2003.
Inhibition of Tumor Growth of Human Breast, Prostate, Colon and Melanoma Cancer Xenografts by Nutrient Synergy in Nude Mice (2003)
Roomi MW, Roomi NW, Ivanov V, Netke SP, Niedzwiecki A, Rath M.
Suppression of MMP Expression and Invasion of Human Cervical Cancer Cell lines Hela and DoTc2 4510 by Nutrients
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Proceedings of the 44th Annual Meeting of the Society of Toxicology, Abstract #1494
Expression of matrix metalloproteinase 2 (MMP-2), memebrane-type 1 MMP and tissue inhibitor of matrix metalloproteinase 2 and activation of pro-MMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitorosobis(2-oxopropyl)amine
Katsumichi Iki, Madahiro tsutumi, Akira Kido, Hiroyuki Sakitani, Makoto Takahama, Masatoshi Yoshimoto, Masaaki Motoyama, Kunihiko Tasumi, Tsukasa Tunoda and Yoichi Konishi
Carcinogenesisi vol. 20 no. 7 pp. 1323-1329, 1999
Ascorbic Acid Protects Guinea Pigs from Acute Aflatoxin Toxicity
P. Netke, W. Roomi, C. Tsao, A. Niedzwiecki
J. Toxicol. 143, 429-435. (1997)
Ascorbate Affects Proliferation of Guinea Pigs Vascular Smooth Muscle Cells by Direct and Extracellular Matrix Mediated Effects
V. O.Ivanov, S. Ivanova, A. Niedzwiecki
J.Mol.Cell.Cardiol. 29, 3293-3303 (1997)
Pharmacokinetics of tranexamic acid in patients with ulcerative colitis and in healthy volunteers after the single instillation of 2 g rectally.
Almer, S., Andersson, T., Strom, M. (1992) Journal of Clinical Pharmacology 32: 49-54.
Prophylactic tranexamic acid and epsilon-aminocaproic acid for primary myocardial revascularisation. Hardy, J.F., BElisle, S., Dupont, C., et al. (1998) Thorac Surg 65(2): 371-6.
Non-hereditary angioedema treated with tranexamic acid.
Munch, E.P., Weeke, B. (1985) Allergy 40: 92-97.
Plasmin induced proteolysis and the role of apoprotein(a), lysine and synthetic lysine analogs.
Rath, M. (1992) Journal of Orthomolecular Medicine 7: 17-23.
Tranexamic acid therapy in hereditary angioneurotic oedema.
Rath, M. (2001) Cellular Health Series: The Heart. MR
Treatment of advanced ovarian cancer with fibrinolytic inhibitor (tranexamic acid).
Some, H., Sashida, T., Yosida, M., et al. (1980) Acta obstetrica et gynecologica scandinavica 59: 285-287.
Vitamin C inhibits the growth of a bacterial risk factor for gastric carcinoma: Helicobacter pylori
Green Tea Compound EGCG May Turn Off Chain Reaction of Inflammation, Joint Damage in RA
Zhang, H.M., Wakisaka, N., Maeda, O., et al. (1997). Cancer 32(10):1897-903.
Experimental Biology 2007, Washington, D.C., April 28-May 2, 2007. News release, Federation of American Societies for Experimental Biology.
Specific nutrient combination effects on tax, NF-B and MMP-9 in human T-cell ymphotropic virus -1 positive malignant T-lymphocytes
Harakeh et al. BMC Cancer 2015, 15(Suppl 1):S2
Repression of matrix metalloproteinases and inhibition of cell invasion by a nutrient mixture, containing ascorbic acid, lysine, proline, and green tea extract on human fanconi anemia fibroblast cell lines
M.W. Roomi, N.W. Roomi, B. Bhanap, A. Niedzwiecki*, M. Rath Exp Oncol 2013 35, 1, 20–24
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
Arthritis Research & Therapy 2014, 16:R113
53.Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins.
Biosci Biotechnol Biochem. 2011;75(8):1564-9. Epub 2011 Aug 7.
Effect of L-lysine on nitric oxide overproduction in endotoxic shock.
Br J Pharmacol. 1997 Oct;122(4):742-8.
51. L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs.
Pediatr Res. 2004 Jun;55(6):979-87.
Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase.
Biochem. Biophys. Res. Commun. 288, 1200–1206 (2001)
